Risk of Blood Clots Tied
to Hormonal Contraceptives
Contraceptives Create 3-to 6-fold increased risk of blood clots.
nonusers, women who use oral contraceptive pills have a 3- to
6-fold increased risk of venomous thromboembolic events, or
blood clots. Risk is greater for pills that contain
third-generation progestins (desogestrel or gestodene) than
those containing levonorgestrel. Oral hormone replacement
therapy similarly creates 2- to 4-fold increase risk of blood
clots compared with nonusers. Women who have an inherited
tendency toward blood clotting and use oral contraceptive pills
or hormone replacement therapy are at greatest risk.1
of Venous Thromboembolic Disease Associated With Hormonal
Contraceptives and Hormone Replacement Therapy, Arch Intern Med.
Vol. 164 October 11, 2004; pp. 1965-1976